apalutamide will lessen the level or influence of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medication which have been CYP3A4 substrates can result in lower publicity to those medicines.armodafinil will reduce the